The Effects of Oral Doses of Theophylline
نویسنده
چکیده
The effects of oral doses of theophylline and a iS-adrenergic agonist, fenoterol, were examined in 18 asthmatic young adults. Significant bronchodilation was seen with high-dose theophylline (FEy1 increased 14 percent) and with full 10-mg doses of fenoterol (FEV, increased 10 percent). Low-dose theophylline alone (130 mg) increased FEV1 by 5 percent, but when combined with 5 mg of fenoterol, a 14 percent improvement was seen, demonstrating significant (P=.003) additive effects. The ability of the two drugs to prevent the asthmatic response to exercise was not additive. The mean fall in FEV1 was not statistically different when subjects ex-
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تاریخ انتشار 2006